A review of pharmacokinetics and relevance to loco-regional anaesthesia of available anti-haemostatic agents in South Africa

SN Griessel; L Firfiray

A review of pharmacokinetics and relevance to loco-regional anaesthesia of available anti-haemostatic agents in South Africa

Authors

SN Griessel Stellenbosch University https://orcid.org/0009-0000-3557-9890
L Firfiray Stellenbosch University https://orcid.org/0000-0002-4071-7917

Keywords:

pharmacokinetics, loco-regional anaesthesia, anti-haemostatic agents

Abstract

Perioperatively, patients on anti-haemostatic agents present anaesthetists with unique challenges. Besides careful consideration of the overall bleeding versus thrombosis risks, the risks versus benefits of loco-regional anaesthetic techniques must be balanced with the risks of perineural haematoma formation and neurological damage. This article reviews the pharmacokinetics of available anti-haemostatic agents in South Africa in relation to the performance of loco-regional anaesthesia.

Author Biographies

SN Griessel, Stellenbosch University

Tygerberg Hospital, Stellenbosch University, South Africa

L Firfiray, Stellenbosch University

Tygerberg Hospital, Stellenbosch University, South Africa

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Published

2025-02-28

Issue

Vol. 31 No. 1 (2025)

Section

Clinical reviews

License

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