FCA 1 Anaesthetic Refresher Course

Atypical opioids

S. Mayet
Southern African Journal of Anaesthesia and Analgesia | Vol 29, No 6 | a1485 | DOI: https://doi.org/10.36303/SAJAA.3052 | © 2023 S. Mayet | This work is licensed under Other
Submitted: 30 November 2025 | Published: 30 December 2023

About the author(s)

S. Mayet, Department of Anaesthesia, School of Clinical Medicine, Faculty of Health Sciences, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, South Africa

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Abstract

Opiates and opioids remain the main pillars of analgesia. Their use is, however, limited by abuse potential as well as their side effect profile. Thus, there is a need for the development of newer opioids. The atypical opioids tramadol, tapentadol, dextromethorphan (DXM), and buprenorphine are newer synthetic opioids. These opioids do not solely depend on mu-receptor agonism for their analgesic effects. Except for DXM, atypical opioids are now being used more than conventional opioids as part of chronic pain management.

Keywords

atypical opioids; chronic pain management

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