FCA 1 Anaesthetic Refresher Course

Intermediary metabolism

S. Dingezweni
Southern African Journal of Anaesthesia and Analgesia | Vol 29, No 6 | a1472 | DOI: https://doi.org/10.36303/SAJAA.3050 | © 2023 S. Dingezweni | This work is licensed under Other
Submitted: 30 November 2025 | Published: 30 December 2023

About the author(s)

S. Dingezweni, Department of Anaesthesia, School of Clinical Medicine, Faculty of Health Sciences, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, South Africa

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Abstract

In humans, chemical unity in diversity prevails as metabolic pathways are coordinated, regulated, and integrated to protect the body against metabolic catastrophes. The end product of one metabolic pathway is connected to another metabolic pathway of the same or another metabolite. A basic understanding of the normal metabolic pathways and their abnormality is the foundation in the management of patients subjected to the stress of anaesthesia and surgery. Objective clinical evaluation, investigations, and perioperative risk stratification of patients are based on understanding the fundamentals of intermediate metabolism.

Keywords

intermediary metabolism; essential intracellular chemical processes

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