An applied pharmacokinetic approach to adjusted drug dosing: Part I – physiological states

Abstract

A patient's age, weight, gender, and pathophysiological state are some factors that may necessitate the adjustment of drug dosing. In addition, pharmacokinetics and pharmacogenomics, drug-drug and food-drug interactions may further alter the pharmacokinetics and pharmacodynamics of a drug. In part I of this topic, the basic principles of pharmacokinetics and the physiological factors that affect drug dosing viz. extremes of age and pregnancy are discussed.