Dextropropoxyphene is dead? Long live....

  • Anthony G Beeton
Keywords: Dextropropoxyphene, withdrawn,


On 20 April 2011, the Medicines Control Council (MCC) announced its decision to withdraw all dextropropoxyphene-(DPP-) containing products from the South African market within three months, because of stated safety risks and an insufficiently weighted risk-benefit profile. These risks refer to dose-related cardiac conduction abnormalities associated with QT prolongation, provoked by the main metabolite of DPP, norpropoxyphene. Cases of fatal arrhythmias have been described.

Author Biography

Anthony G Beeton
Anaethetist Private Practice
Guest Editorial