General anaesthesia with and without intubation for patients with Cornelia de Lange syndrome

Authors

  • Yoshinao Asahi Morinomiya Hospital
  • Ikuko Tsujimoto Morinomiya Hospital
  • Yusuke Kawai Morinomiya Hospital
  • Masahiro Sugimoto Morinomiya Hospital
  • Takahiro Suzuki Morinomiya Hospital
  • Shiro Omichi Bobath Memorial Hospital
  • Mikihiko Kogo Osaka University
  • Junichiro Kotani Osaka Dental University

Keywords:

general anaesthesia, Cornelia de Lange syndrome, dental treatment

Abstract

We present the use of different methods of general anaesthesia in two patients with Cornelia de Lange syndrome and its contribution to the patients’ oral health. Case 1: The patient was a 22-year-old woman with Cornelia de Lange syndrome who underwent dental treatment under general anaesthesia. She exhibited the physical characteristics of Cornelia de Lange syndrome, including a small mouth, thin lips, short limbs, stiffness of joints and intellectual disability. General anaesthesia without intubation was performed safely eight times. No other complications except hypersensitivity to hypnotic agents were observed. Case 2: The patient was a 10-year-old boy with Cornelia de Lange syndrome who underwent dental treatment under general anaesthesia. He had a history and symptoms of obstructive airway disorders in addition to showing physical characteristics of the syndrome similar to those seen in Case 1. General anaesthesia with nasal intubation was performed safely twice. Computed tomography (CT) of his head and neck produced unremarkable results. These cases demonstrate that both general anaesthesia with and without nasal intubation can be safely used in managing individuals with Cornelia de Lange syndrome during dental treatment. Peer reviewed (Submitted: 2009-05-22, Accepted: 2009-08-13)

Author Biographies

Yoshinao Asahi, Morinomiya Hospital

DDS, PhD Dentist-Anaesthesiologist Department of Dentistry, Morinomiya Hospital

Ikuko Tsujimoto, Morinomiya Hospital

DDS, PhD Oral Surgeon Department of Dentistry Morinomiya Hospital

Yusuke Kawai, Morinomiya Hospital

MD, PhD Anaesthesiologist Department of Anesthesia Morinomiya Hospital

Masahiro Sugimoto, Morinomiya Hospital

MD, PhD Anaesthesiologist Department of Anesthesia, Morinomiya Hospital

Takahiro Suzuki, Morinomiya Hospital

MD, PhD Anaesthesiologist Department of Anesthesia, Morinomiya Hospital

Shiro Omichi, Bobath Memorial Hospital

DDS, PhD Paediatric Dentist Department of Dentistry Bobath Memorial Hospital

Mikihiko Kogo, Osaka University

DDS, PhD Oral Surgeon The First Department of Oral and Maxillofacial Surgery Division of Pathogenesis and Control of Oral Disease Osaka University Graduate School of Dentistry

Junichiro Kotani, Osaka Dental University

DDS, PhD Dentist-Aaesthesiologist Department of Anesthesiology Osaka Dental University

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Published

2009-08-13

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Section

Case Studies