Contrast and dyes
Contrast agents have long been used for the imaging of anatomic boundaries and to explore normal and abnormal physiologic findings. The introduction of increasingly faster and more discriminating radiographic imaging techniques has resulted in the need for radiation-attenuating contrast agents that can be used in traditional radiographic imaging or, more recently, in subtraction imaging, both of which can be projected and rotated in three dimensions. By far the most successful and widely applied contrast agents in use today are the iodinated contrast agents (ICAs), first introduced into clinical practice in the 1950s.1 It is estimated that approximately 75 million doses of ICAs are given worldwide each year.
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