An update on malignant hyperthermia diagnostics and anaesthetic machine preparation for patients at risk in Africa

  • J C Brand Mediclinic Midstream Hospital
  • P M Hopkins St James’s University Hospital


The EMHG first published its protocol for an in vitro contracture test (IVCT) in 19841 and this has ever since formed the bedrock of clinical diagnosis and phenotyping. In 20152 the EMHG published the updated guidelines for investigation of malignant hyperthermia susceptibility. Evidently the rigour of the IVCT stood the test of time and was used in more than 10 000 individuals worldwide to define their MH risk, representing an example of preventative medicine and improved patient safety.

Author Biographies

J C Brand, Mediclinic Midstream Hospital
Malignant Hyperthermia Centre Mediclinic Midstream Hospital
P M Hopkins, St James’s University Hospital
Malignant Hyperthermia Unit Leeds Institute of Biomedical and Clinical Sciences St James’s University Hospital Leeds
FCA Refresher Course